Our platform technologies have been scaled from single nozzles to variations of multi-nozzles, then another order of magnitude by simply running multi-nozzles in parallel. Good for small molecules, proteins, peptides, and vaccines.Can be used to inject and set up highly concentrated depots of a drug.Film-forming agent dries quickly on warm biological surfaces.Film-forming agent uses a non-irritating aqueous base.Combines Stratµm™ microspheres with a film forming agent, or film-forming agent alone.Good for oral small molecules, nutraceuticals, agricultural applications, flavorings, and heat stable molecules.Compatible with waxes, lipids, stearates, gelatins.Particle sizes down to 75 μm with Span values as low as 0.40.Good for injectable small molecules, proteins, peptides, vaccines, and heat-labile molecules.Compatible with PLGAs, PLAs, PCLs, PCPHs, alginates, gelatins, and other biopolymers.Particle sizes down to 10 μm with ± 5% deviation from the mean diameter.The platform technology has been divided into three subcategories: Stratµm™, Optimµm®, and Unisun®. Scaled multi-nozzles have been developed for two- and three-stream flow for producing solid microspheres (Figure A) and core-shell microcapsules (Figure B). It delivers on the promise of precision microparticles at a previously unachievable scale. The Precision Particle Fabrication™ platform was developed with industry in mind. Not to mention, the compatibility with a wide range of excipients and particle sizes enables unique functionality and product opportunities for creating first-in-class prescription formulations or matching complex modified release profiles of over-the-counter products. In Figure B, three-fluid nozzle adds further control over particle architecture by adjustment of “core” and “shell” flow rates, in addition to vibratory frequency. In Optimµm® technology, the carrier stream is comprised of air or nitrogen, which is analogous to spray congealing or prilling. In Stratµm™ technology, the carrier stream is comprised of water, which is analogous to emulsion processes. For any given mass flow rate, droplet size can be reduced simply by increasing the frequency of vibration. In Figure A, uses a two- or three- fluid vibrating nozzle with co-flowing axial “carrier” stream used to reduce jet diameter the use of both physical mechanisms simultaneously is patent-protected. Not to mention, Adare can achieve the same small sizes with a shell layer. Conversely, Adare’s process allows production of those same 25 micrometer particles (and much smaller) with sufficiently large orifice diameters. This is why all other scaleable uniform microsphere technologies are limited to a size of ~ 150 micrometers. Such a small orifice does not allow passage of viscous solutions or concentrated suspensions, fouls easily after a small number of uses, and is not a scalable approach. For instance, in other vibratory processes, producing uniform 25 micrometer droplets requires machining a ~13 micrometer hole in a nozzle body. Other vibratory technologies fall short because the smallest achievable particle size is governed by the orifice diameter. Seamlessly integrate into current processesĪdare uses two physical processes simultaneously to create uniform droplets: piezoelectric vibration and a co-flowing non-solvent “carrier” stream.Sustained, delayed, pulsatile release profiles.Proven capability to produce a variety of construction and release profiles: Macromolecules, polymers, nucleic acids, proteins.

Small molecules (hydrophilic and hydrophobic).Production rates of kg/hr to kg/min, depending on the applicationįlexible and customizable to accommodate almost any active ingredient:.Controlled diameter from 10 μm up to 1 mm.Figure AĬontinuous-flow, high-volume nozzle technology with precise control over key attributes responsible for controlled release, including size, composition, coating, and materials. That means new ways to improve and differentiate your products, including their delivery, efficacy, and safety. With unprecedented control of particle size, previously hidden doors are suddenly open.

Orbis’ technology is an elegant and robust solution with countless applications. Precision Particle Fabrication™ technology produces uniform microspheres and microcapsules with narrow size distribution and precise control over particle structure.

Orbis technologies massachusetts